急性脑梗死患者血清可溶性CD40L与C反-应蛋白含量的改变及其意义

Changes and its significance of serum content of soluble CD40L and C-reactive protein in patients with acute cerebral infarction

目的探讨急性脑梗死(ACI)患者血清可溶性CD40L(sCD40L)和C-反应蛋白(CRP)含量的改变及其意义。方法采用双抗体夹心酶联免疫法及比浊法检测40例ACI患者及30人正常对照者的血清sCD40L和CRP含量,比较不同病情、不同梗死面积ACI患者的血清sCD40L和CRP含量变化,对二者之间的关系进行相关性分析。结果ACI组血清sCD40L[(3.57±0.86)ng/ml]、CRP[(17.53±7.61)mg/L]的含量明显高于正常对照组(均P<0.01),ACI病情重度组、大面积梗死组血清sCD40L、CRP的含量明显高于病情中度、轻度组和小面积、腔隙性脑梗死组,病情中度组、小面积梗死组又明显高于病情轻度组、腔隙性脑梗死组(均P<0.05)。血清sCD40L与CRP含量呈正相关(r=0.817,P<0.01)。结论ACI患者血清sCD40L、CRP含量升高,并与病情严重程度和梗死面积有关。提示其可作为判断ACI病情的血清生物学指标。

Objective To investigate the changes and its significance of serum content of soluble CD40L （sCIMOL） and C-reactive protein（CRP） in patients with acute cerebral infarction（ACI）. Methods The content of serum sCIMOL and CRP in 40 patients with ACI and 30 normal controls were measured by enzyme-linked immunosorbent assay and immunonphelometry. The content of serum sCD40L and CRP were compared in the patients of different pathogenetie condition and infarction size. The correlation between sCD40L and CRP and pathogenetic condition and infarction size were analysised. Results The contents of serum sCD40L and CRP in ACI group were significantly higher than normal control group （all P 〈0. 01 ）. The content of serum sCD40L and CRP in the patients with serious state of illness and large size infarction were significantly higher than those in the middle-light state of illness and small size or lacuna infarction groups, the patients with middle state of illness, small size infarction were significantly higher than those in the light state of illness and lacuna infarction groups （ all P 〈 0. 05 ）. The content of serum sCD40L had positive correlation with the content of CRP （r = 0. 817, P 〈 0. 01 ）. Conclusions The contents of serum sCD40L and CRP increase in the patients with ACI, and witch are correlated with the illness state and infarction size. Which register that sCD40L and CRP are the indexes of serum biology in ACI condition.