急性脑梗死患者血浆溶血磷脂酸、总磷脂和低密度脂蛋白水平的改变及其与颈动脉粥样硬化的关系

Changes and correlation between the levels of plasma lysophosphatidic acid,acid phospholipid,low density lipoprotein and carotid artery atherosclerosis in patients with acute cerebral infarction

目的研究急性脑梗死(ACI)患者溶血磷脂酸(LPA)、总磷脂(AP)、低密度脂蛋白(LDL)水平的改变及其与颈动脉粥样硬化的关系。方法应用多普勒超声仪检测67例ACI患者和30名正常对照者的颈动脉,用有机溶剂抽提法测定血浆LPA、AP含量,用酶直接法测定血浆LDL含量。结果ACI组血浆LPA、AP和LDL水平显著高于正常对照组(均P<0.01);ACI颈动脉软斑块组、混合斑块组血浆LPA水平显著高于硬斑块组(均P<0.01),各斑块组血浆AP、LDL水平差异无统计学意义。结论ACI患者血浆LPA、AP、LDL水平增高,ACI合并颈动脉不稳定斑块患者的血浆LPA水平显著高于稳定性斑块患者。提示血浆LPA的水平可以反映颈动脉粥样硬化斑块的稳定性。

Objective To investigate the changes and the correlation between the levels of plasma lysophosphalidic acid （LPA）, acid phospholipid （AP）, low density lipoprotein（LDL） and carotid artery atherosclerosis in patients with acute cerebral infarction （ACI）. Methods The levels of plasma LPA, AP and LDL were examined in 67 ACI patients and 30 normal controls,the carotid arteries were investigated with B mode ultrosand. Results The levels of plasma LPA,AP and LDL were higher in ACI group than those in the normal control group（ all P 〈 0. 01 ） , the concentrations of LPA in soft plaque group and mixed plaque group were higher than that in sclerotic plaque group （all P 〈 0. 01 ）. There was no significant difference of the levels of plasma AP and LDL among those groups. Conclusions The plasma LPA,AP and LDL levels are elevated in patients with ACl,the level of plasma LPA in cases of ACI with unstable plaque group is higher than whom with stable plaque. It suggests that the level of LPA can reflect the stabitity of plaque of carotid artery atherosclerosis.