药对柴胡-白芍对大鼠体内外血小板聚集的影响

Effects of herb-pairs of Chaihu-Baishao on platelet aggregation in rat in vitro and in vivo

目的:观察调肝理气类药对柴胡-白芍对大鼠体内外血小板聚集作用的影响。方法:制备各中药水煎液,灌胃给药,观察柴胡-白芍对药及各单味中药对大鼠血小板聚集的影响。结果:调肝理气类药对柴胡-白芍,单味中药柴胡、白芍体内给药对大鼠血小板聚集性有显著抑制作用(P<0.01);体外给药则无明显影响。结论:柴胡、白芍及二者配伍的药对通过体内给药,具有一定的抗ADP诱导的大鼠血小板聚集作用。

Objective ： To observe the effects of herb - pairs of qi Tiaogan Chaihu - Baishao on platelet aggregation in rat in vitro and in vivo. Methods ： Preparated the decoction of Chinese medicine, the effects of Chaihu - Baishao and single herbs on rat platelet aggregation were observed after intragastric administration. Results： the rat platelet aggregation in vivo in hera - pairs of qi Tiaogan Chaihu - Baishao group and Chaihu group and Baishao group were notably refrained （ P 〈 0. 01 ） ; however, there is no effects in vitro. Conclusion ： Chaihu, Baishao and the herb - pairs of the two have a certain degree of anti - ADP - induced platelet aggregation in rats in vivo.