代谢异常与冠状动脉狭窄程度的相关性

RETROSPECTIVE STUDY OF THE RELATIONSHIP BETWEEN ABNORMAL METABOLISM AND SEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS WITH CORONARY ANGIOGRAPHY

目的：探讨代谢异常与冠状动脉狭窄程度的相关性。方法：收集整理本院2007-2008年间372例冠心病患者的临床资料,排除急性心急梗死及资料不全者。其中男性251例。回顾分析其冠状动脉造影结果。按照不同的冠状动脉病变积分分组,建立各个生化指标之间的联系,对比研究不同病变程度的代谢异常情况。结果：经单因素分析随冠状动脉狭窄程度的增加,年龄、男性比例、血糖、LDL-C、吸烟、血尿酸、TC均有显著升高,而HDL-C显著降低（F=7.47-2.70,P=0.001-0.045）。相关性分析表明冠状动脉狭窄严重程度与年龄、血尿酸、性别、HDL、Glu、LDL、糖尿病病史、吸烟、TC、TG有相关性（r=0.219-0.089,p=0.000-0.042）。回归分析表明年龄为冠心病最显著的危险因素（OR=1.982 95%可信区间为1.191-3.299 P=0.008）。结论：年龄、性别、血糖、尿酸、HDL和总胆固醇是冠心病最主要的相关危险因素,但其它代谢异常亦不可忽视。

Objective：To evaluate the correlation between abnormal metabolism and the extent and severity of angiographic coronary artery disease（CAD） in patients with coronary angiography. Methods：A retrospective study was performed including consecutive CAD patients（ male 251, female 79）with average age of 57. 17 ± 11.25. The extent and severity of angiographic CAD was diagnosed by the number of diseased vessels and the CAD Gensini cumulative index. Analyses were achieved by univariate and multivariate analysis. Results：It indicates by univariate analysis that a positive correlation was found between coronary severity and age, gender, serum glucose, LDL cholesterol, smoking, uric acid, total cholesterol （ F = 7.47 - 2. 70 p = 0. 001 - 0. 045 ） ; a negative correlation was found between coronary severity and HDL cholesterol（ F =2. 86 p =0. 0367）. Study by Spearman＇ s correlation analysis showed that age,gender, HDL cholesterol, serum glucose, LDL cholesterol, smoking, TC, TG were prominent predictor of the extent and severity of angiographic CAD. Conclusion ：The age ,gender, serum glucose ,uric acid, HDL cholesterol and total cholesterol were related to the severity of CAD.