常山胡柚皮的化学成分分离鉴定(英文)

Isolation and identification of chemical constituents from peels of Citrus changshan-huyou Y.B.Chang

目的:分析常山胡柚(Citrus changshan-huyouY.B.Chang)皮的化学成分。方法:利用反复硅胶柱色谱分离和纯化,并通过波谱分析鉴定化合物结构。结果:分离并鉴定了10个化合物结构,分别为胡柚皮甲素(Ⅰ)、3-羟基-4-甲氧基苯甲酸(Ⅱ)、3,4-二羟基苯甲酸(Ⅲ)、脂肪酸(Ⅳ)、甘油酯(Ⅴ)、6,7-二甲氧基香豆素(Ⅵ)、6′,7′-二羟基香柠檬亭(Ⅶ)、胡萝卜苷A(Ⅷ)、胡萝卜苷B(Ⅸ)和胡柚三萜(Ⅹ)。结论:胡柚皮甲素为新化合物;这10个化合物均为首次从该植物中分得。

Objective ： To study the chemical constituents of the peels collected from Citrus changshanhuyou Y. B. Chang, and further screen the bioactive components as the lead structures. Methods： These compounds were isolated by repeated flash column chromatography on silica gel and Sephadex LH- 20. The structures of isolated compounds were elucidated by using IR, ELMS, and NMR analyses. Resuits： One novel compound along with nine known compounds were obtained and identified as huyoujiasu （ Ⅰ ）, 3-hydroxy-4-methoxybenzoic acid （ Ⅱ ）, 3,4-dihydroxybenzoic acid （ Ⅲ）, fatty acid （ Ⅳ ）, glyceride（ Ⅴ ）, 6,7-dimethoxycoumarin （Ⅵ）, 6＇, 7＇-dihydroxybergamottin （ Ⅶ）, daucossterol A （ Ⅷ ）, daucossterol B（Ⅸ） and huyou-triterpenoid（ Ⅹ ）. Conclusion： One new compound, Huyoujiasu, was obtained from these peels by repeated column chromatography, and the other known compounds were isolated from this fruit for the first time as well.