基于调控细胞凋亡的肿瘤化疗增敏策略

Tumor chemosensitization strategies based on apoptosis manipulations

肿瘤多药耐药(multidrug-resistance,MDR)是肿瘤治疗中面临的一大难题。肿瘤对化疗药物产生耐药性的机制十分复杂,除癌细胞膜药物外排泵(Pgp等)过度表达所致外,细胞凋亡敏感性的异常变化也是其主要机制之一。文章综述了肿瘤凋亡通路异常改变引起耐药性的研究进展以及通过调整紊乱的凋亡通路克服MDR的策略。

MDR（multidrug-resistance） is a major obstacle in the chemotherapy of cancer. Numerous mechanisms are known to contribute to MDR, alterations at the level of apoptosis control are one of those mechanisms except overexpression of drug efflux pumps. This review focuses on the research progression of altera-tions at the level of apoptosis inducing MDR, and some of the strategies that have been used in an attempt to chemosensitize resistant tumors by manipulating dysregulated apoptosis pathways.