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内分泌胰腺嘌呤受体研究的新进展 被引量：2

Recent developments in purinergic receptors of endocrine pancreas
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摘要 嘌呤受体分为腺苷作用的P1受体和ATP作用的P2受体两大类;P2受体又分为P2X(离子通道受体)和P2Y(G蛋白耦联受体)。多种嘌呤受体亚型表达于内分泌胰腺,并参与调节胰岛素的分泌。嘌呤受体和配体与糖尿病及其并发症的发病机制密切相关,并可能成为糖尿病及其并发症治疗的新靶点。 Purinergic receptors are divided into P1 （adenosine） and P2 （ATP） receptors. P2 receptor are divided into two subtypes,namely P2X （ligand-gated ion channels） and P2Y （G- protein coupled） receptors. Several kinds of purinoceptor subtypes have been expressed in endocrine pancreas and participate in regulating the secretion of insulin. Purinoceptor and ligand are correlated with pathogenesis of diabetes mellitus and complications and make it possible to provide a new target to treat diabetes mellitus and complications.
作者 李桂林 梁尚栋
机构地区 南昌大学基础医学院生理学教研室
出处 《中国药理学通报》 CAS CSCD 北大核心 2009年第10期1275-1277,共3页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助课题(No30860086 30660048 30460040) 教育部高校博士点专项科研基金资助课题(No20070403007) 江西省自然科学基金资助课题(No0640042) 江西省教育厅科技研究资助项目(No赣教技字[2007]60号和GGJ08049)
关键词 嘌呤受体 核苷酸 内分泌胰腺 胰岛素分泌 糖尿病 治疗 purinoceptors nucleotide endocrine pancreas se-cretion of insulin diabetes mellitus therapeutics
分类号 R-05 [医药卫生] R322.491 [医药卫生—人体解剖和组织胚胎学]
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参考文献25

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  • 4Richards-Williams C,Contreras J L,Berecek K H,Schwiebert E M.Extracellular ATP and zinc are co-secreted with insulin and activate multiple P2X purinergic receptor channels expressed by islet beta-cells to potentiate insulin secretion[J].Purinergic Signal,2008,4,393-405.
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二级参考文献39

共引文献24

同被引文献22

  • 1王明霞,任雷鸣,王红芳.细胞外ATP和腺苷及其受体与细胞凋亡[J].中国药理学通报,2006,22(9):1029-1034. 被引量：5
  • 2Inoue K.UDP facilitates microglial phagocytosis through P2Y6 receptors[J].Cell Adh Migr,2007,1(3):131-2.
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  • 6Wu L J,Vadakkan K I,Zhuo M.ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents[J].Glia,2007,55(8):810-21.
  • 7Honda S,Sasaki Y,Ohsawa K,et al.Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-Coupled P2Y receptors[J].J Neurosci,2001,21(6):1975-82.
  • 8Liu G J,Nagarajah R,Banati R B,et al.Glutamate induces directed chemotaxis of microglia[J].Eur J Neurosci,2009,29(6):1108-18.
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引证文献2

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中国药理学通报
2009年 第10期

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