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C型利钠肽:肾脏自稳态平衡的重要效应分子 被引量：2

C-type natriuretic peptide:an important effector molecule for renal homeostasis
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摘要 C型利钠肽(C-type natriuretic peptide,CNP)主要表达于中枢神经系统和血管内皮细胞,通过自分泌或旁分泌途径来维持肾脏自稳态平衡,在水盐代谢、血管舒缩、肾小球滤过膜通透性和细胞增殖分化等方面发挥重要的调控效应。对CNP肾脏代谢特点的阐释,有望为病理状态下评估肾脏损害、施行靶向治疗开辟新思路。 C-type natriuretic peptide （CNP）, mainly expressed in central nervous system and vascular endothelial cells maintains renal homeostasis by autocrine or paracrine pathway, which regulates water-electrolyte metabolism, vascular resistance, glomerular permeability, and cell proliferation. Thus, clarifying the characteristics of CNP metabolism in kidney would appear promising to develop some new prospects for the evaluation of kidney injury and the targeted therapy.
作者 胡鹏 鹿玲 胡波 覃远汉
机构地区 安徽医科大学第一附属医院儿科 广西医科大学第一附属医院儿科
出处 《中国药理学通报》 CAS CSCD 北大核心 2009年第10期1386-1389,共4页 Chinese Pharmacological Bulletin
关键词 C型利钠肽 自稳态平衡 肾脏 中性肽链内切酶 血管紧张素 血管平滑肌细胞 C-type natriuretic peptide homeostasis kidney neutral endopeptidase angiotonin vascular smooth muscle cell
分类号 R-05 [医药卫生] R322.61 [医药卫生—人体解剖和组织胚胎学]
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参考文献27

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二级参考文献20

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同被引文献18

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中国药理学通报
2009年 第10期

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