冠心病危险因素定量积分评估与冠状动脉病变的关系研究

Relationship between three quantitative assessments of risk factors of coronary heart disease and severity of coronary lesions

目的:探讨危险因素定量评估在冠心病诊疗中的作用,为指导冠心病防治提供理论依据。方法:按特定标准选出282例行冠状动脉(CA)造影患者,分别进行3种积分(Fram ingham积分、PROCAM积分和中国积分)评估,分析三者与CA病变支数、狭窄程度、CA阻塞积分之间的相关关系,评价其在预测冠心病发病率的价值。结果:3种积分的危险因素定量评定与CA病变支数、狭窄程度、CA阻塞积分呈正相关,其中PROCAM积分相关性最高,Fram ingham积分最低。积分数值越大,CA病变支数越多,病变程度越重。对冠心病发生率预测的受试者工作特征(ROC)曲线下面积,PROCAM积分最大,Fram ingham积分最小。结论:3种危险因素定量评估积分可在一定程度上反映CA病变程度,对冠心病的发病有一定的预测价值,其中PROCAM积分的预测价值最优。

Objective： Various quantitative assessments of coronary heart disease（CHD） risk factors was performed to evaluate severity and predicting its occurrence rate.Methods：282 cases,were selected to be scored by Framingham,PROCAM（The Prospective Cardiovascular Munster Study） and Chinese risk scores respectively.We compared the relationship between three risk scores and severity,extent of coronary artery through correlation analysis,and subsequently analyzed their predictive value.Results： Chinese risk score,PROCAM risk score,Framingham risk score were significantly correlated with extent and severity of coronary artery atherosclerosis（CAAS）,with PROCAM risk score,the highest correlation of it and Framingham risk score,the smallest.Risk scores increased with coronary artery pathological change advancing.The areas under resident operation character（ROC） of Framingham risk score was the least,whereas that of PROCAM was the largest.Conclusion： Among the three risk scores described above used to evaluate the severity of CAAS and predict incidence of CHD,PROCAM risk scores was the superior.