速度矢量成像检测成人隐匿性自身免疫性糖尿病亚临床左室功能不全

Evaluation of subclinical left ventricular systolic and diastolic function with velocity vector imaging in patients with latent autoimmune diabetes in adults

目的:探讨速度矢量显像(VVI)评价亚临床状态的成人隐匿性自身免疫性糖尿病(LADA)患者左室心肌长轴节段收缩功能的价值。方法:声学采集60例单纯LADA患者和60例健康志愿者心脏动态数字化图像,获取16节段心肌长轴方向的速度、应变、应变率及其达峰时间进行分析。结果:LADA组收缩期和舒张期心肌速度、应变率及收缩期、舒张早期心肌应变明显低于对照组(P<0.01)。舒张晚期心肌应变两组比较差异无统计学意义(P>0.05)。LADA组各节段速度、应变、应变率的达峰时间较对照组有延长趋势,但差异无统计学意义(P>0.05)结论:VVI技术可无创性定量分析LADA患者心肌收缩、舒张功能,为早期评价亚临床状态的LADA患者心肌运动功能异常提供了一种新的可靠的工具。

Objective To assess subclinical left ventricular systolic and diastolic function in normotensive latent autoimmune diabetes in adult（LADA） patients with normal ejection fraction and fractional shortening by velocity vector imaging（VVI）.Methods Digital dynamic imaging of 60 normotensive LADA patients and another 60 healthy subjects were collected.The longitudinal velocity,strain,and strain rate were measured in systolic,early and later diastolic period respectively and the peak time of velocity,strain,and strain rate were recorded.The parameters were analyzed.Results Compared with the control group,all of the measured parameters of LADA patients were significantly lower（P〈0.01）,except the later diastolic strain（P〉0.05）.The peak time of myocardial longitudinal velocity,strain and strain rate was lengthened compared with the control group,but without statistical significance（P〉0.05）.Conclusion VVI is a novel and noninvasive tool to quantitatively and objectively assess left ventricular regional systolic and diastolic function in the LADA patients.It can make trustworthy early diagnose of abnormal left ventricle myocardial performance in patients with subclinical LADA.