左旋千金藤定碱抗心律失常作用的研究

Anti-Arrhythmic Effects of L-stepholidine

目的研究左旋千金藤定碱(L-stepholidine,SPD)抗心律失常的作用.方法采用实验性动物心律失常模型,探讨SPD的抗心律失常效应.结果SPD对BaCl2诱发的大鼠心律失常有明显的对抗作用,并能显著降低CaCl2所致大鼠的室颤发生率和死亡率,对强心苷所致的心律失常也有明显的保护作用.结论SPD具有明显的抗心律失常作用.

Objective To observe anti-arrthythmic effects of L-stepholidine anti-arrhythmic effects of SPD were investigated on experimental arrhythmic animal （SPD）. Methods The models trigged by BaCl2, CaCl2, or cardiac glycosides （digoxin, strophanthin K, and lanatoside）. Results SPD was able to antagonize arrhythmia trigged by BaCl2 in rats, and was able to decrease ventricular fibrillation incidence and mortality trigged by CaCl2 in rats, further more, SPD showed protective effects on arrhythmia caused by cardiac glycosides in guinea pigs. Conclusion SPD has significant anti-arrhythmic effects.