围产儿23 323例出生缺陷监测分析

The Analysis of Birth Defects in 23 323 Perinatal Neonates

目的了解我院13a年来围产儿出生缺陷的发生率和种类,探索出生缺陷影响因素,以便采取有效干预措施.方法按照《中国出生缺陷监测表》及诊断标准进行进行监测分析.结果我院13a共住院分娩围产儿23323例,出生缺陷儿248例,缺陷儿总发生率为10.63‰,单发畸形206例,多发畸形42例,肌肉骨骼系统、颌面耳颈部和消化系统畸形最为常见.前7位各系统分布顺位依次为:泌尿生殖系统、神经系统、心血管系统及染色体病.经产妇缺陷儿发生率高于初产妇(P<0.01).结论加强围产期保健,提高产前诊断水平,有利于早期发现缺陷儿,早期终止妊娠(孕28周前),减少出生缺陷的发生,提高人口素质.

Objective To get informations on the prevalence of birth defects during 1996 - 2008, in order to take effective intervention measures. Methods According to ＂China Birth Defects Monitoring Form＂ and diagnostic criteria for monitoring and analysis. Results A total of 23, 323 perinatal neonates, who were born in hospital in recent 13 years were included in this study. The number of birth defects neonates in total was 248, and the prevalence of birth defects was 10.63 %0. 206 of the cases were neonates with single malformation, while 42 of cases were those with multiple malformations. The musculoskeletal abnormalities were the most prevalent. The birth defects was more popular in pluriparas than that of primiparas （P 〈 0.01 ）. Conclusion Improving the level of prenatal diagnosis and perinatal care will be of advantage in improving the quality of the population.