2型糖尿病患者下肢血管病变的发生率及危险因素分析

Incidence and Risk Factors of the Vascular Disease in Lower Limbs of Patients with Type 2 Diabetes

目的了解2型糖尿病患者下肢血管病变(PVD)发生率,分析PVD的相关危险因素.方法2型糖尿病280例进行多普勒血流探测仪检查.比较下肢血管病变组与正常对照组生化指标间的差异,并对病变的危险因素采用logistic回归方法进行分析.结果多普勒血流探测仪检查显示下肢血管病变者占62.2%(174/280).PVD有关的危险因素包括年龄、病程、收缩压、舒张压、低密度脂蛋白胆固醇、血尿酸、空腹血糖、餐后2h血糖,其中独立危险因素有年龄、收缩压、低密度脂蛋白胆固醇和餐后2h血糖(OR分别为1.164、1.066、5.693、1.214).结论2型糖尿病下肢血管病变发生率高,高血压、高血脂、高血糖是其独立危险因素,严格控制血压、血脂、血糖,有利于预防和减少下肢血管病变的发生.

Objective To investigate the incidence and analyze the risk factors of the vascular disease in lower limbs of patients with type 2 diabetes. Methods The vascular disease in lower limbs of 280 subjects with type 2 diabetes were tested by Doppler ultrasonic blood stream detector. Clinic data between Diabetes and control groups were compared, and risk factors were analyzed by logistic regression. Results There were 62.2% （174/280） patients who had vascular disease in lower limbs with type 2 diabetes. The related risk factors of PVD included age ,course of disease, SBP,DBP,LDL,UA, FBG 2 h BG , and independent risk factors were age, SBP, LDL, 2hBG （OR： 1.164, 1.066, 5.693, 1.214）. Conclusion There is higher incidence of the vascular disease in lower limbs of patients with type 2 diabetes, and the independent risk factors are hypertension, hyperglycemia, hyperlipemia. Strictly control of blood pressure, blood fat, and glucose can help prevent and reduce the incidence rate of the vascular disease in lower limbs with type 2 diabetes.