血清纤维化标志物与慢性肝炎患者肝纤维化关系的研究

The Relation between Fibrosis Marker of Patients with and Liver Cirrhosis

目的研究血清透明质酸(HA)、IV型胶原(IVC)及层粘蛋白(LN)与慢性肝病、肝纤维化的关系.方法对100例慢性肝病患者用放射免疫法检测血清HA、IVC、LN水平及定量PCR检测血清HBC-DNA.结果血清HA、IVC、LN水平与慢性肝病的发展呈正相关,且在肝硬化阶段处于最高水平,(P<0.01).结论血清HA、IVC、LN水平可反映慢性肝病的病情轻重,动态观察其变化可掌握病情演变,并可作为肝纤维化血清检测指标.

Objective To explore the of correlation hepatic cirrhosis of patients with chronic hepatitis. Method between, hyaluronic, IV collagen, laminin and Radio immunoassay was used to detect serum levels of HA, IVC and LN of 100 patients withe chronic hepatitis, and real-time PCR was used to detect serum HBC-DNA. Result Serum levels of HA, IVC, LN and the chevelopment of chronic liver disease were positively correlated and at the hiyhest level in liver cirrhosis, （ P 〈 0.01 ）. Concision HA, IVC, LN, can reflect the condition of chronic hepatitis, It＇ s helpful for us to observ these markers dynamidy, it also can be as a indicator of hepatic cirrhosis.