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NADPH氧化酶介导的氧化还原信号转导在高同型半胱氨酸血症中的作用及分子机制 被引量：3

NADPH Oxidase-Mediated Redox Signaling in Hyperhomocysteinemia
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摘要 同型半胱氨酸(homocysteine,Hcy)是一种含硫氨基酸,是甲硫氨酸代谢的中间产物。目前大量的临床试验及流行病学研究证实,高同型半胱氨酸血症(血浆中同型半胱氨酸浓度大于15μmol/L)是一些硬化性疾病的一个独立危险因子,其中包括动脉粥样硬化、冠心病、阿尔茨海默氏病、糖尿病、终末期肾病及其相关的心血管并发症等。由NADPH氧化酶介导的氧化应激被认为是高同型半胱氨酸血症重要的病理生理机制之一。本文将在国内外相关研究的基础上,结合我们课题组在研究高同型半胱氨酸血症所致肾小球损伤中的研究成果,对NADPH氧化酶在高同型半胱氨酸血症中的调控机制及生理意义做一简要综述。 Homocysteine is a thiol-containing amino acid and an intermediate product of methionine metabolism. Numerous epidemiological and clinical studies have indicated that hyperhomocysteninemia （plasma homocysteine level is above 15 μmol/L） is a risk factor for many sclerostic diseases such as atherosclerosis, cardiovascular diseases, Alzheimer diseases, diabetes, end stage renal disease （ESRD） and so on. NADPH oxidase- mediated oxidative stress is considered as one of important mechanisms in the development of hyperhomocysteinernia- induced various diseases. In this review, based on recent studies by our group exploring the mechanisms of glomerular injury in hyperhomocysteimia and by others, we summarized recent findings that reveal the contribution of homocysteine as a pathogenic factor to the development of various diseases and discussed the related mechanisms on the regulation of NADPH oxidase activity and its physiological role in hyperhomocvsteinemia.
作者 李国华 魏欣冰 张岫美 易凡
机构地区 山东大学医学院药理学研究所
出处 《细胞生物学杂志》 CSCD 2009年第5期602-607,共6页 Chinese Journal of Cell Biology
关键词 高同型半胱氨酸血症 NADPH氧化酶 氧化应激 硬化性疾病 hyperhomocysteinemia NADPH oxidase oxidative stress sclerostic diseases
分类号 R589 [医药卫生—内分泌]
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参考文献36

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同被引文献24

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细胞生物学杂志
2009年 第5期

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