药用植物细胞次生代谢产物合成信号转导机制研究进展

Progress in Signal Transduction Mechanism of Secondary Metabolite Biosynthesis in Medical Plant Cells

植物细胞中次生代谢产物的低产现象是制约细胞培养法生产植物次生代谢产物技术产业化应用的核心问题之一。与初生代谢相比,植物次生代谢具有非常强的可调控性。细胞内部的信号转导系统是介导植物次生代谢产物合成的桥梁和纽带。近年来,国内外研究者对植物细胞次生代谢信号转导途径进行了广泛的研究。本文介绍了这一领域的最新研究进展,并结合本课题组的研究结果重点阐述了NO、SA、JA、ROS等信号分子(途径)在介导植物细胞次生代谢产物合成中的关系及相互影响。

The intracellular signal systems play important roles in plant secondary metabolite biosynthesis induced by multiple biotic and abiotic elicitors. Many signal molecules such as nitric oxide （NO）, jasmonic acid （JA）, salicylic acid （SA）, and reactive oxygen species （ROS） have been demonstrated to be involved in mediating the elicitor-induced secondary metabolite biosynthesis of plant cells. Furthermore, the cross-talking of NO-, SA-, JA-, and ROS-dependent signaling pathways in elicitor-induced secondary metabolite production has been characterized in plants. Moreover, a few recent studies have suggested that a signal network responsible for the regulation of the biosynthesis of secondary metabolites may exist in plant cells. The newest progress in the signal mechanism of secondary metabolite biosynthesis of plant cells has been reviewed in this paper.