循环肿瘤细胞与个体化药物治疗

Circulating tumor cells and individualized chemotherapy

循环肿瘤细胞(circulating tumorcells,CTC)已经被证实存在于肿瘤患者尤其是晚期患者的外周血中。近年来CTC的研究技术迅速发展并且在肿瘤个体化药物治疗方面显示出良好的发展前景。CTC的重要性在于它可以使基因表达/突变的检测变得切实可行,从而实现"实时"个体化药物治疗。本文主要介绍现有的CTC检测/收集技术及其在个体化药物治疗方面的作用。

Circulating tumor cells （CTC） have been identified in peripheral blood from cancer patients especially those with metastatic lesions. Recently, the analysis of CTC has been developed rapidly and showed good prospects for individualized chemotherapy. The field of CTC research is very important since gene-expression profiling becomes feasible and real time when using CTC as the sample of evaluation. This review was to summarize present CTC detection, enrichment, or both methods and their contribution to individualized chemotherapy.