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多胺类似物及其抗肿瘤作用机制 被引量：3

Progress of polyamine analogue and its antineoplastic mechanism
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摘要 多胺类似物是一类研发中的新型抗肿瘤药物。在肿瘤细胞内,多胺类似物通过干扰正常多胺代谢耗竭肿瘤快速生长必需的多胺成分、影响DNA结构和功能、调节肿瘤相关基因表达水平、改变细胞周期和诱导细胞凋亡等途径发挥抗肿瘤效应。本文就多胺类似物及其抗肿瘤的作用机制作一综述。 Polyamine analogue is a new type of antitumor agents. The antitumor effects of polyamine analogue were exerted by interfering with polyamine metabolism and depleting the polyamine intracellular, which were necessary for the proliferation of tumor cell, affecting the structure and function of DNA, regulating tumor related gene, changing cell cycle, and inducing apoptosis. This paper reviews polyamine analogue and its antineoplastic mechanism.
作者 任玉珊 韩钰 王艳林
机构地区 三峡大学分子生物学研究所 三峡大学医学院
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2009年第10期731-736,共6页 Chinese Journal of New Drugs and Clinical Remedies
基金 2007年度湖北省教育厅自然科学研究项目(D200713003)
关键词 胺类 肿瘤 抗肿瘤药 多胺类似物 amines neoplasms antineoplastic agents polyamine analogue
分类号 R73 [医药卫生—肿瘤]
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参考文献2

二级参考文献28

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共引文献15

同被引文献53

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中国新药与临床杂志
2009年 第10期

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