期刊文献+

MicroRNA在心血管疾病中作用的研究进展 被引量:1

下载PDF
导出
摘要 microRNA是一类长度在22 nt左右、能调节mRNA表达的非编码RNA基因产物。miRNA最初在线虫体内被发现,广泛存在于真核生物体内,对于生物体的发育等诸多方面有调节作用,并在进化中保守。miRNA作用机制尚不完全清楚,但已知其能通过与mRNA的3′端非翻译区结合而影响翻译水平。现就miRNA的生物发生、作用机制及其在心脏发育、心肌肥厚、动脉粥样硬化、心力衰竭、高血压和心律失常中起的作用的研究进展作一综述。
作者 陈婷 王长谦
出处 《心脏杂志》 CAS 2009年第5期730-734,共5页 Chinese Heart Journal
  • 相关文献

参考文献20

  • 1Sempere LF, Fremantle S, Pitha-Rowe I, et al. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal diferentiation[J]. Genome Bioz, 2004, 5(3):R13.
  • 2Zhao Y, Ransom JF, Li A, et al. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2[J]. Cell, 2007, 129 (2):303-317.
  • 3Kwon C, Han Z, Olson EN, et al. MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signalin g [J]. Proc Natl Acad Sci USA, 2005, 102(52):18986-189991.
  • 4Zhao Y, Samal E, Srivastava D. Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis[J]. Nature, 2005, 436(7048):214-220.
  • 5Sayed D, Hong C, Chen IY, et al. MicroRNAs play an essential role in the development of cardiac hypertrophy[J]. Circ Res, 2007, 100(3):416-24.
  • 6Carè A, Catalucci D, Felicetti F, et al. MicroRNA-133 controls cardiac hypertrophy[J]. Nat Med, 2007, 13(5):613-618.
  • 7Chen JF, Mandel EM, Thomson JM, et al. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation[J]. Nat Genet, 2006, 38(2):228-233.
  • 8Carè A, Catalucci D, Felicetti F, et al. MicroRNA-133 controls cardiachypertrophy[J]. Nat Med, 2007, 13(5):613-618.
  • 9Cheng Y, Ji R, Yue J, et al. MicroRNAs are aberrantly expressed in hypertrophic heart. Do they play a role in cardiac hypertrophy? [J]. Am J Pathol, 2007, 170(6):1831-1840.
  • 10van Rooij E. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure[J]. Proc Natl Acad Sci USA, 2006, 103(48):18255-18260.

二级参考文献14

  • 1Hong MK, Mintz GS, Abizaid AS, et al. Intravascular ultrasound assessment of the presence of vascular remodeling in diseased human saphenous vein bypass grafts[J]. Am J Cardiol, 1999, 84(9): 992-998.
  • 2Gonzlez MC, Arrobas SM, Molero F, et al. Effect of removal of adventitia on vascular smooth muscle contraction and relaxation [J].Am J Physiol Heart Circ Physiol , 2001,280 :H2876 - H2881.
  • 3Schulze-Bauer CAJ, Regitnig P, Hotzapfer GA. Mechanics of the human femoral adventitia including the high pressure response[J].Biomech,2002,282 (6): H2427 - H2440.
  • 4Stenmark KR, Gerssimovskaya E, Nemenoff RA, et al. Hypoxic activation of adventitial fibroblasts role in vascular remodeling [J].Chest, 2002,122:326s - 334s.
  • 5Bayer IM, Adamson SL, Langille BL. Atrophic remodeling of the artery-cuffed artery [J]. Arterioscler Thomb Vasc Biol, 1999,19(6): 1499 - 1505.
  • 6Brasunwald 陈灏珠.心脏病学[M](第5版)[M].人民卫生出版社,2000.1001-1006.
  • 7Han Y,Runge MS, Brasier AR. Angiotensin Ⅱ induces interleukin6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-kappa B transcription factors [J]. Circ Res,1999,84(6) :695 -703.
  • 8Lauth M, Berger MM ,Cattarazza M, et al. Elevated perfusion pressure upragulates endothelin-1 and endothelin β receptor expression in the rabbit carotid artery[J]. Hypertension, 2000, 35 (2) :648 -654.
  • 9Schoenhangen P, Ziada KM, Vince DG, et al. Arterial remodeling and coronary artery disease:the concept of "dilated" versus "obstructive" coronary artherosclerosis[J]. J Am Coll Cardiol, 2001,38:297 - 306.
  • 10Jorgensen B, Simonsen S, Endresen K, et al. Restenosis and clinical outcome in patients treated with Amlodipine after angioplasty:results from CAPARES[J]. Am Coll Cardiol, 2000,35 ( 3 ) :592 -599.

共引文献10

同被引文献21

  • 1Weber M, Baker MB, Moore JP, et al. MiR-21 is induced in endo- thelial cells by shear stress and modulates apoptosis and eNOS activ- ity [ J ]. Biochem Biophys Res Commun, 2010, 393 (4) :643 - 648.
  • 2Sarkar J, Gou D, Turaka P, et al. MicroRNA-21 plays a role in hy- poxia-mediated pulmonary artery smooth muscle cell proliferation and migration[ J]. Am J Physiol Lung Cell Mol Physiol, 2010, 299 (6) :861 -871.
  • 3Davis BN, Hilyard AC, Lagna G, et al. SMAD proteins control DROSHA-mediated microRNA maturation [ J]. Nature, 2008, 454 (7200) :56 -61.
  • 4Parikh VN, Jin RC, Rabello S, et al. MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach [ J ]. Circulation, 2012, 125 ( 12 ) : 1520 - 1532.
  • 5Yang S, Banerjee S, Freitas Ad, et al. MiR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling[ J ]. Am J Physiol Lung Cell Mol Physiol, 2012, 302(6) :521 -529.
  • 6Yan L, Hao H, Ehon TS, et al. Intronic microRNA suppresses en- dothelial nitric oxide synthase expression and endothelial cell prolif- eration via inhibition of STAT3 signaling [ J ]. Mol Cell Biochem, 2011, 357(1 -2): 9-19.
  • 7Courboulin A, Paulin R, Gigure NJ, et al. Role for miR-204 in human pulmonary arterial[J]. J Exp Med, 2011, 208(3): 535- 548.
  • 8Brock M, Trenkmann M, Gay RE, et al. Interleukin-6 modulates the expression of the bone morphogenic protein receptor type Ⅱ through a novel STAT3-microRNA cluster 17/92 pathway[ J]. Circ Res, 2009, 104(10) : 184 -1191.
  • 9Bonnet S, Rochefort G, Sutendra G, et al. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeu- tically targeted [ J ]. Proc Natl Acad Sci U S A, 2007, 104 (27) : 11418 - 11423.
  • 10Guo L, Qiu Z, Wei L, et al. The microRNA-328 regulates hypoxic pulmonary hypertension by targeting at insulin growth factor 1 recep- tor and L-type calcium channel-alC [ J]. Hypertension, 2012, 59 (5) : 1006 -1013.

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部