膀胱残余尿水平与良性前列腺增生患者肾功能和尿路感染的关系

The relationship of bladder residual urine volume and renal function and urinary tract infection in patients with benign prostatic hyperplasia

目的探讨膀胱残余尿水平和良性前列腺增生（BPH）患者肾功能及尿路感染的关系。方法回顾性分析接受手术治疗并经病理证实为单纯BPH的病例81例，分成A组53例（残余尿量〈60m1），B组18例（残余尿量60～200m1），C组10例（残余尿量〉200m1）。对三组患者的血尿素氮、血肌酐、尿细菌培养结果作对照研究。结果A、B、C组的血尿素氮、血肌酐分别为（5．90±3．01）mmol／L、（90．13±25．08）μmol／L和（7．85±3．53）mmol／L、（128．36士30．25）μmol／L以及（10．57±4．01）mmol／L、（152．11±36．68）μmol／L，C组血尿素氮、血肌酐水平明显高于A组（P〈0．01）和B组（P〈0．05），而B组亦明显高于A组（P〈0．05）。A、B、C组尿路感染的发生率分别为28．3％（15，53）、44．4％（8／18）、50．0％（5／10），A组与B、C组比较差异有统计学意义（P〈0．05），而B组和C组比较差异无统计学意义（P〉0．05）。大肠埃希菌仍为尿路感染的主要病原菌。结论随着膀胱残余尿量的增多，BPH患者肾功能损害有加重趋势。当残余尿量≥60ml时则明显增加了尿路感染的发生率。

Objective To study the relationship of bladder residual urine volume and renal function and urinary tract infection in patients with benign prostatic hyperplasia（BPH）. Methods Eighty-one BPH cases from September 2005 to September 2008 were studied retrospectively. All the cases were divided into group A （53 cases, the residual urine volume 〈 60 ml ）, group B （ 18 cases, the residual urine volume 60-200 ml）,and group C （10 cases, the residual urine volume 〉 200 ml）. Blood urea nitrogen（BUN）, serum creatinine （Cr） and urine bacterial culture were observed. Resullts The BUN and serum Cr in group A, B and C were （5.90 ± 3.01 ） mmol/L, （90.13 ± 25.08 ）μmol/L, （7.85± 3.53 ） mmol/L, （ 128.36 ± 30.25 ） μmol/L and （10.57 ± 4.01 ）mmol/L, （152.11 ±36.68）μmol/L, respectively. The BUN and serum Cr in group C were higher than those in group A and B （P 〈 0.01 or 〈 0.05）. And there was significant difference between group A and group B （P 〈 0.05 ）. The incidence of urinary tract infection in group A , B and C was 28.3%（ 15/53 ）,44.4%（8/18）,50.0%（5/10）, respectively. There was significant difference between group A and group B,C（P〈 0.05）. But there was no significant difference between group B and group C（P〉 0.05）. Escherichia was the main bacteria in urinary tract infection. Conclusion The increase of bladder residual urine volume in patients with BPH enhances renal failure and urinary tract infection.