双歧杆菌脂磷壁酸对衰老小鼠胸腺Bcl-2、Fas基因表达的影响

Effect of Lipoteichoic Acid from Bifidobacterium on Bcl-2、Fas Gene Expression in Aging Mice

目的研究双歧杆菌脂磷壁酸对D-半乳糖致衰老小鼠胸腺组织Bcl-2、Fas基因表达的影响,探讨双歧杆菌脂磷壁酸的抗衰老机制。方法用D-半乳糖建立衰老小鼠模型,以双歧杆菌脂磷壁酸治疗,反转录-聚合酶链反应法观察小鼠胸腺Bcl-2、Fas基因mRNA表达。结果与正常对照组比较,模型组Bcl-2基因表达降低,Fas表达水平升高,差异有统计学意义(P<0.01);与模型组比较,治疗组Bcl-2基因表达升高,Fas表达水平降低,差异有统计学意义(P<0.01)。结论双歧杆菌脂磷壁酸能降低衰老小鼠Fas表达水平,增加Bcl-2表达,具有抗衰老作用。

Objective To study the effect of lipoteichoic acid（ LTA）from bifidobacterium on Bel-2, Fas gene expressinn in aging mice. Methods To build the mice model of aging by inject D-glactose and treated with LTA,then obseve mRNA expressinn of Bcl-2 ,Fas gene in thymus of mice. Results Compared with the normal cnntrnl group,mRNA expression of Bcl-2 gene in the model groups was decreased and expression of Fas gene was increased（ P 〈0. 01 ）. Compared with the model group,mRNA expression of Bel-2 gene in LTA groups was increased and expression of Fas gene was decreased（ P 〈0.01 ）. Conclusion ITA can incerease the expression of Bcl-2 geoe and decrease the expressinn of Fas gene.LTA have action on antiaging.