骨桥蛋白与多发性硬化

The Relation between Osteopontin and Multiple Sclerosis

骨桥蛋白(OPN)是一种多效性的结合蛋白,可作为致炎因子参与多种自身免疫性疾病发病。OPN在不同临床类型多发性硬化(MS)患者血浆中的水平有所不同,OPN在损伤过程中不同程度的表达与疾病的严重程度密切相关,且在动物模型实验性变态反应性脑脊髓炎(EAE)研究中同样发现,OPN是发病关键因子之一。OPN在MS及其EAE发病机制中起着重要作用,可能与OPN作为一种免疫应答的诱导物,影响Th1/Th2平衡,调节IL-10、IL-12、肿瘤坏死因子α等细胞因子的释放有关。研究OPN的作用将有助于MS发病机制的探索,并且为临床治疗提供新思路。

Osteopontin（OPN）is a pleiotropic intergrin binding protein,functioned as the inflammatory cytokine in many autoimmune diseases.OPN expresses differently in different clinical forms of multiple sclerosis（MS）,the contant of OPN is closely correlated with it.OPN also plays a key role in the research of experimental autoimmune encephalomyelitis（EAE）.The mechanism of how OPN influence MS may be explained by the imbalance of Th1/Th2,the release of IL-10、IL-12 and TNF-αby it.To study the function of OPN may help to know the mechanism of MS and supply a new idea.