结直肠癌的中医治疗进展

Research Progress of Traditional Chinese Medicine Treatment on Colorectal Cancer

本文综述1996年到2009年23篇有代表性文章,将中医在早中期结直肠癌抗转移复发的队列研究和随机研究、在晚期结直肠的随机研究或病例对照研究、在围手术期和放化疗期的随机对照或病例对照研究进行综述,一方面证实坚持中医治疗,对于结直肠癌根治术后的患者可能减少复发和转移;对晚期患者可能延长生存期,改善生活质量;对围手术期患者可能促进结直肠癌术后胃肠功能恢复,增强免疫力;对于放疗、化疗的患者可能预防或减轻放、化疗不良反应,值得深入探讨。另一方面提出目前在国内发表的文献多为小样本的临床研究或经验报道,大样本、多中心、随机双盲等高质量的临床研究不多,在循证医学中的证据水平不高,系统评价尚不能得出定量结论。

This paper reviewed 23 representative articles from 1996 years to 2009 about Traditional Chinese medicine treatment （TCM）to coloreetal cancer. TCM treatment to colorectal cancer is reviewed in the early and middle stages of colorectal cancer to anti-metastasis and anti-recurrence of cohort study and randomized study,in advanced colorectal randomized studies or ease-control study, in the peri-operative period and radiotherapy and chemotherapy randomized controlled or case-control studies. On the one hand,the paper confinn that it may reduce the recurrence and metastasis for patients who had a radical surgery for colorectal cancer to adhere to TCM treatment; it may prolong survival and improve quality of life for in advanced patients; it may contribute to coloreetal cancer patients with postoperative gastrointestinal function recovery and strengthen the immune system; it also may prevent or reduce adverse effect of radiotherapy and chemotherapy patients. So TCM treatment of eoloreetal cancer should be further explored. On the other band, the author points out the present published literature in domestic are mostly small samples of clinical research or experience reports. High-quality clinical researches with large sample,muhi-center, randomized double-blind are poor. Evidence level in evidence-based medicine is not high, systematic evaluation are still unable to reacli quantitative conclusions.