摘要
目的:探讨男性肝硬化患者血清性激素水平的变化及其临床意义。方法:采用放射免疫分析测定118例肝硬化患者和108例正常健康人的血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)及泌乳素(PRL),以进行比较。结果:肝硬化患者血清T、E2水平较正常对照组显著降低(P<0.01),血清PRL含量则高于对照组(P<0.01),而FSH、LH变化不大。结论:男性肝硬化患者体内存在性激素水平的失衡和紊乱,联检血清T、E2、PRL含量对估测肝硬化的严重程度及预后具有实用价值。
Objective To study the clinical significance of changes of serum levels of sex hormones in male patients with liver cirrhosis.Methods The concentration of serum follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),testosterone(T) and prolactin(PRL) were examined with RIA in 118 male patients with liver cirrhosis and 108 controls.Results The levels of serum T and E2 were significantly lower in the patients than those in the controls(P〈0.01) while the levels of serum PRL were significantly higher than those in controls(P〈0.01).The FSH and LH levels in patients were not significantly different from those in controls(P〉0.05).Conclusion There are disturbances of sex hormones metabolism in male patients with liver cirrhosis.Simultaneous measurement of T,E2 and PRL can help to predict prognosis of liver cirrhosis.
出处
《放射免疫学杂志》
CAS
2009年第4期340-341,共2页
Journal of Radioimmanology
关键词
男性
肝硬化
性激素
male liver cirrhosis sex hormones