西咪替丁治疗轮状病毒肠炎中呕吐的疗效评估

Evaluation of Curative Effect in Treatment of Vomit in Rotavirus Enteritis by Cimetidine

目的评估西咪替丁在治疗轮状病毒肠炎中呕吐症状的疗效。方法将127例小儿轮状病毒肠炎住院患儿随机分为3组,治疗组2组,即A、B治疗组及对照组C组。3组均患儿均采用常规治疗,A治疗组在上述治疗基础上加用西咪替丁(10～15mg/kg·d),B治疗组在上述治疗基础上加用山茛菪碱(0.2～0.3μg/(kg·d)。结果A、B治疗组与对照组在平均止吐时间上差异显著,A、B两治疗组间疗效差异显著;不良反应发生率A、B治疗组差异显著。结论西咪替丁治疗轮状病毒肠炎中呕吐症状的疗效较山茛菪碱更有效、安全。

Objective It is to observe the curative effect in treatment of vomit in rotavirus enteritis by Cimetidine. Methods 127 infantile patients of rotavirus enteritis are randomly divided into three groups：two treated groups（A,B groups）and one contrast group （C group）.All infants are treated with conventional therapy. On the basis of conventional therapy,A group is given by taking Cimetidine （10～15mg/kg·d）.And on the basis of the above therapy,B group is given by taking additional Scopolamine（0.2～ 0.3μ g/kg·d）.Results There is significant difference between A and B treated Groups and contrast group in Inaverage time of stopping expectorating.Also,there are predominant differences between A group and B group. In adverse effect rate, A,B groups are predominant differences.Conclusion Taking Cimetidine is much more effective and safer than taking Scopalamine in treatment of vomit in rotavirus enteritis.