2型糖尿病患者护骨素基因启动子区950T→C多态性与血管并发症的关系

Relationship between polymorphism of osteoprotegerin gene promoter 950T→C and vascular complications in type 2 diabetic patients

目的探讨2型糖尿病患者护骨素(OPG)基因启动子区950T→C多态性与合并冠心病、脑血管病、视网膜病变的关系。方法采用聚合酶链反应-限制性片断长度多态性(PCR-RFLP)法检测OPG基因型。结果 OPG基因启动子区950T→C多态性与糖尿病合并冠心病、脑血管病无明显相关性(P>0.05),而与视网膜病变相关,合并视网膜病变患者C等位基因比例显著高于无视网膜病变患者(χ2=4.696,P<0.05)。结论 C等位基因可能增加2型糖尿病并发视网膜病变的遗传易感性。

Objective To study the relationship of polymorphism of osteoprotegerin （OPG） gene promoter 950T→C with coronary artery disease, cerebrovascular disease and retinopathy in type 2 diabetic （T2DM） patients. Methods Gene polymorphism of osteoprotegerin was detected by PCR-RFLP techniques. Results There were no associations of OPG promoter genotypes with coronary artery disease and cerebrovascular disease（all P〉0. 05）. The frequency of C allele was significantly higher in the subjects with versus without retinopathy （x^2 = 4. 696, P 〈 0.05） .Conclusions The C allele may increase the susceptibility to retinopathy in type 2 diabetic patients.