空腹血糖与OGTT 2小时血糖在糖尿病前期诊断方面的比较研究

Comparison of prediabetes diagnostic rate between FPG and OGTT 2hPG measuement

目的采用美国糖尿病学会2003年标准,比较空腹血糖(FPG)和2hPG(OGTT)判定糖耐量异常的能力。方法研究对象均在同一天早晨空腹抽血后立即进行OGTT,Kappa 一致性比较检测FPG和2hPG两种方法的诊断能力。结果 1197例患者中,共检出807例(67.4%)正常血糖者、267例(22.3%)糖尿病前期患者和123例(10.3%)糖尿病患者。与2hPG相比,FPG能显著提高糖尿病前期的检出率,但明显降低了糖尿病的检出率;与之相反,2hPG能显著提高糖尿病的检出率,但明显降低糖尿病前期的检出率。结论采用FPG联合OGTT 2hPG测定能提高糖尿病前期的检出率。

Objective To compare the prediabetes diagnosis rate based on FPG versus OGTT 2hPG. Methods All subjects were enrolled for FPG and OGTT 2hPG detection,and Kappa agreement measure was used to check the consistency between the FPG and OGTT 2hPG. Results A total of 1197 Chinese subjects were recruited into the study. We detected 807 （67.4%） NGT, 267（22.3%） IGT and 123 （10. 3%） DM subjects, respectively. The FPG test, compared with 2-hr OGTT test, can increase the diagnostic proportion of prediabetes, but decrease the proportion of DM. In contrast to this, 2h OGTT test can increase the diagnostic proportion of DM, but decrease the proportion of prediabetes. Conclusions The combined FPG and 2h OGTT test can increase the detection rate of prediabetes.