两种胰岛素治疗方案对2型糖尿病患者血糖波动性的影响被引量：1

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摘要目的观察预混人胰岛素30R与门冬胰岛素联合甘精胰岛素两种治疗方案对2型糖尿病患者血糖波动性的影响。方法40例初诊的2型糖尿病(T2DM)患者(空腹血糖>11.1mmol/L,HbA1c>9.0%),按1∶1随机分为A、B两组,A组给予预混人胰岛素30R(诺和灵30R),B组给予门冬胰岛素(诺和锐)和甘精胰岛素(来得时)进行治疗。以空腹及餐后2h指尖毛细血管血糖分别小于7.0mmol/L和10.0mmol/L为目标,用动态血糖检测仪监测患者血糖水平,计算全天血糖水平的标准差(SDBG),平均血糖波动幅度(MAGE)以及空腹血糖变异系数(CV-FBG)作为反映血糖波动指数。结果治疗后B组SDBG、MAGE和CV-FBG三个指标均低于A组[SDBG:(1.48±0.41)vs(1.75±0.43)mmol/L;MAGE:(3.24±0.75)vs(3.86±1.02)mmol/L;CV-FBG:(16.35±2.34)vs(19.43±3.25),均P<0.05],同时B组低血糖发生次数也低于A组,但差异无统计学意义(P>0.05)。结论与诺和灵30R相比,联合应用门冬胰岛素和甘精胰岛素治疗方案更有利于血糖平稳。

作者徐文浩潘芳

机构地区湖北省孝感市中心医院内分泌科

出处《中国现代医生》 2009年第31期16-17,共2页 China Modern Doctor

关键词糖尿病血糖波动门冬胰岛素甘精胰岛素

分类号 R587.1 [医药卫生—内分泌]

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1The Diabetes Control and Complication Trial Research Group. The relationship of glycemic exposure (HbA1C) to the risk of development and progression of retinopathy in the diabetes control and complication trial[J]. Diabetes, 1995,44(8) : 968-983.
2Bruu E,Zoppini G,Zamboni C,et al. Glucose instability is associated with a high level of circulating pselectin[J]. Diabetes Care,2001,24(9) : 1685.
3Muggeo M, Zoppini G, Bonora E, et al. Fasting plasma glucose variability predicts 10-year survival of type 2 diabetic patlents:the Verona Diabetes Study[J]. Diabetes Care,2000,23( 1 ) :45-50.
4Quagliaro L,Piconi L,Assaloni R,et al. Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells.The role of Protein kinase C and NAD(P)H oxidase activation[J]. Diabetes, 2003,52 ( 11 ) : 2795-2804.
5Piconi L, Quagliaro L, Da Ros R, et al. Intermittent high glucose enhances ICAM-1,VCAM-1,E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly (ADP-ribose) polymerase[J]. J Thromb Haemost, 2004,2(8) : 1453-1459.