VEGF和c-Myc在血管瘤不同时期的表达

Expression of VEGF and c-Myc during Different Stages of Dermal Hemangiomas

目的:探讨血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)和c-Myc在血管瘤不同时期的作用。方法:采用免疫组织化学SP法检测56例血管瘤标本(增殖期30例,消退期26例)中VEGF和c-Myc的表达。统计学分析采用SPSS11.0统计软件。结果:VEGF在增殖期血管瘤组织中均呈阳性表达,阳性率为100%;而在消退期血管瘤中阳性率为61.54%;两组之间的差异有显著性(P<0.05)。c-Myc在增殖期血管瘤中阳性率为76.67%,在消退期血管瘤组织中的阳性率为100%,两组之间的差异有显著性(P<0.05)。结论:VEGF在增殖期血管瘤血管内皮细胞上高表达,促进血管瘤增殖;在消退期血管瘤血管内皮细胞上低表达,有利于血管瘤消退。c-Myc在增殖期血管瘤血管内皮细胞上低表达,有利于血管瘤增殖;在消退期血管瘤的血管内皮细胞上高表达,促进血管瘤消退。增殖期血管瘤中c-Myc和VEGF协同作用,可能促进血管瘤的增殖;血管瘤消退期中,VEGF低表达时,高表达的c-Myc可能加速血管瘤消退。

Objective： To investigate the expression intensity of VEGF and c-Myc in different growing stages of dermal hemangioma. Methods： 56 hemangiomas （30 in proliferative stage and 26 in involutional stage） were examined immunohistochemically by SP method. Statistical analysis was carried out using the program SPSS for Windows 11.0. Results： VEGF expression in proliferative hemangiomas was 100%, whereas in involutional hemangiomas was 61.54%, there was significant difference between groups （P〈0.05）. c-Myc expression in proliferative hemangiomas was 76.67%, whereas in involutional hemangiomas was 100%. There was significant difference between groups（P〈0.05）. Conclusion： VEGF may contribute in the development of hemangiomas, c-Myc may contribute in the involution of hemangiomas. VEGF and c-Myc have collaborative actions that promote the proliferation of hemangiomas. When lacking of VEGF, the c-Myc can promote the involution of hemangiomas.