176例失代偿期肝硬化预后影响因素的回顾分析

A retrospective analysis on factors influencing the prognsis of decompensation cirrhosis in 176 cases

目的探讨失代偿期肝硬化预后的影响因素。方法对176例失代偿期肝硬化的临床资料进行回顾性分析,根据患者预后分为死亡组与存活组,比较两组Child-Pugh分级、终末期肝病模型(MELD)评分、并发症发生率及数量。结果乙型肝炎是发生肝硬化的主要原因,死亡组Child-Pugh、MELD分值均显著高于存活组(P<0.01),所有患者合并至少一种并发症,死亡组在腹水、感染、电解质紊乱、肝性脑病(HE)、上消化道出血、肝肾综合征(HRS)发生率及合并并发症数量也显著高于存活组(P<0.05,P<0.01)。结论Child-Pugh、MELD分值及并发症均影响失代偿期肝硬化患者转归,可作为评价此病预后的重要指标。

Objective To explore the factors influencing the prognsis of decompensation cirrhosis. Methods Clinical data of 176 decompensation cirrhosis were analyzed retrospectively, cases were divided into alive group and dead group according to their proghsis, the MELD and Child - Pugh scores, complication of the two groups were compared. Results Hepatitis B is a main cause of cirrhosis, MELD and Child -Pugh scores were higher in dead group than alive group （P 〈 0.01 ）. All case had not less than one kind complication, the dead group was higher than the alive in abdominal effusion, infections, disorder of electrolyte, hepatic encephalopathy（ HE）, gastrointestinal hemorrhage, and hepatorenal syndrome （HRS） incidences and complication numbers （P 〈 0. 05,P 〈 0. 01 ） o Conclusion MELD scores, Child - Pugh grading and complications can influence survival rate of decompensation cirrhosis and be used as important indicators to determine prognsis of the disease.