401例类风湿关节炎患者中医证候要素分析

Analysis on traditional Chinese medicine syndroms of 401 rheumatoid arthritis patients

目的对类风湿关节炎(rheumatoid arthritis,RA)患者的中医症状及相关资料进行统计分析,探讨其结果与相关指标间的关系。为RA的证候学研究及临床治疗提供依据。方法采用临床流行病学的方法设计调查问卷,收集分析资料,利用多元统计方法进行数据统计。结果401例RA患者中医症状可归纳为寒、热、虚3个公因子,可分为寒证、热证、虚证、寒热错杂证、虚寒证、虚热证6类证候。差异性统计分析结果提示健康问卷调查评分、血小板、类风湿因子、抗角蛋白抗体在各证候间有统计学差异(P<0.05)。结论重庆地区RA患者中以寒热错杂证多见,热证多见于疾病活动期,而稳定期多见寒证,RA疾病活动性与中医证候相关。

Objective To investigate the traditional Chinese medicine （ TCM） syndromes of rheumatoid arthritis （ RA） by studying the Chinese medical patterns,and analyze the correlations of different indicators and related syndromes. Methods The questionnaires were designed according to clinical epidemiological theories. The data were collected and analyzed by multivariate statistical methods. Results The TCM symptoms of the 401 cases of RA were concluded into 3 common factors,that is,cold,heat and deficient. Their syndromes were sub-classified as 6 groups： cold syndrome,heat syndrome,deficiency,cold heat complex,deficient cold and asthenic fever. Statistical analysis showed that there were significant differences in health assessment questionnaire （ HAQ） ,platelet （ PLT） ,rheumatoid factor （ RF） ,anti-keratin antibody （ AKA） among these 6 TCM syndromes （ P〈0. 05） . Conclusion RA patients in the Chongqing region have more cold heat complex. Heat syndrome is particularly prevalent in the disease activity period,and cold syndrome is more common in stable period. RA disease activity is associated with the TCM syndrome.