1Ohta M, Inoue H, Cotticelli MG, et al. The FHIT gene, spanning the chromosome 3 p 14.2 fragile site and renal carcinoma-associated t (3 ; 8 ) breakpoint, is abnormal in digestive tract cancers [ J ] . Cell, 1996,84(2) :587 -597.
2Kannan K, Munirajan AK, Bhuvarahamurthy V, et al. FHIT gene mutations and single nucleotide polymorphism in Indian oral and cervical squamous cell carcinomas [ J ] . Oral Oncology, 2000,36 ( 1 ) : 189 - 193.
3Paradee W, Mullins C, He Z, et al. Pricise localiztion of aphidicolin- induced breakpoints on the short ann of human chromosome [ J ] . Genomics, 1995,27 (2) : 358 -361.
4Chaudhuri AR, Khan I A, Prasad V, et al. The tumor suppressor protein Fhit. A novel interaction with tubulin [J]. J Biol Chem, 1999 , 274(3) : 24378 -24382.
5Roz L, Gramegna M, Ishii H, et al. Restoration of fragile histidine triad ( FHIT ) expression induces ap- optosis and suppresses tumorigenicity in lung and cervical cancer cell lines [ J ]. Proc Natl Acad Sci USA, 2002, 99(2) : 3615 -3620.
6Ishii H, Dumon KR, Vecchione A, et al. Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells [ J ]. Cancer Res, 2001, 61 ( 3 ) : 1578 -1584.
7Pace HC, Garrison PN, Robinson AK, et al. Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit [ J ]. Proc Natl Acad Sci USA, 1998, 95(1) : 5484 -5489.
8Maitra A, Wistuber Ⅱ, Washington C, et al. High-resolution chromosome 3 p alletotyping of breast carcinomas and precursur lesions denmonstrates frequent loss of heterozigosity and discontinuous pattern of allele loss [ J]. Im J Pathol, 2001, 159(1) :119 -134.
6Paradee W, Mullins C, He Z, et al. Pricise localiztion of aphidicolininduced breakpoints on the short arm of human chromosome 3 [J] . Genomics,1995,27(2) :358 -361.
7Siprashvili Z, Sozzi G, Barnes LD,et al. Replacement of Fhit in cancer cells suppresses tumorigenicity [J].Proc Natl Acad Sci USA, 1997,94(25): 13771 -13776.
8Dumon KR, Ishii H , Fong LY, et al. FHIT gene therapy prevents tumor development in Fhit - deficient mice [J]. Proc Natl Acad Sci USA,2001,98(6) :3346 -3351.
9Fong LY, Fidanza V, Zanesi N, et al. Muir- Torre - like syndrome in Fhit-deficient mice [J] . Proc Natl Acad Sci USA, 2000, 97 (9):4742 -4747.
10Martinez A, Walker RA, Shaw JA,et al. Chromosome 3 p allele loss in early invasive breast cancer: detailed mapping and association with clinicopathological features [J]. Mol Pathol, 2001, 54 ( 5 ): 300 -306.
3Ohta M,Inoue H,Cotticelli MG,et al.The FHIT gene,spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8)breakpoint,is abnormal in digestive tract cancers[J].Cell,1996,84(4):587-597.
4Bednarek AK,Laflin KJ,Daniel RL,et al.WWOX,a novel WW domain-containing protein mapping to human chromogome 16q23.3-24.1,a region frequently affected in breast cancer[J].Cancer Res,2000,60(8):2140-2145.
5Guler G,Huebner K,Himmetoglu C,et al.Fragile histidine triad protein,WW domain-containing oxidoreduetase protein Wwox,and activator protein 2gamma expression levels correlate with basal phenotype in breast cancer[J].Cancer,2009,115(4):899-908.
6Wang M,Gu J,Wang Y,et al.Loss of WWOX expression in human extrahepatic cholangiocarcinoma[J].J Cancer Res Clin Oncol,2009,135(1):39-44.
8Hassan MI,Naiyer A,Ahmad F.Fragile histidine tried protein:structure,function,and its association with tumorogenesis[J].J Cancer Res Clin Oncol,2010,136(3):333-350.
9Roz L,Andriani F,Ferreira CG,et al.The apoptotic pathway triggered by the Fhit protein in lung cancer cell lines is not affected by Bcl-2 or Bcl-x(L)overexpression[J].Oncogene,2004,23(56):9102-9110.
10Del Mare S,Salah z,Aqeilan RI.WWOX:its genomics,portners,and functions[J].J Cell Biochem,2009,108(4):737-745.
