摘要
目的研究三氧化二砷(As2O3)对HepA小鼠肝癌血管内皮生长因子(VEGF)及环氧合酶-2(COX-2)表达的影响。方法建立皮下种植肝癌小鼠模型,用药后观察小鼠肿瘤体积变化及抑瘤率;利用免疫组化观察移植瘤中VEGF及COX-2。结果三氧化二砷对小鼠肝癌瘤体体积和抑瘤率均具有抑制作用;三氧化二砷降低了VEGF及COX-2的表达,与未用药对照组相比均差异有统计学意义(P<0.05)。结论三氧化二砷能缩小肿瘤体积、增加抑瘤率,并能降低VEGF及COX-2的表达。
Objective To study the effect of arsenic trioxide（ As2O3 ） on vascular endothelial growth factor （VEGF） and cyclooxygenase-2 （COX-2） expression in hepatocarcinoma. Methods HepA - grafed hepatoearcinoma mouse model was established. After treated by As2O3 ,the volume change of tumor and tumor inhibition rates were observed. The expression of VEGF and COX-2 was detected by immunohistoehemistry. Results The volume of tumor and the tumor inhibition rates were significantly decreased in As2O3 group compared with control group （P 〈 0.05） . The As2O3 inhibited angiogenesis of xenografl tumor, depressed the expression of VEGF and COX-2. Conclusion As2O3 can inhibit the growth oftumor, and inhibit the expression of VEGF and COX-2.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2009年第5期435-436,440,共3页
Journal of Harbin Medical University
关键词
小鼠
肝癌
三氧化二砷
血管内皮生长因子
环氧合酶-2
mouse hepatocarcinoma
arsenic trioxide
vascular endothelial growth factor
cyclooxygenase-2
