237例慢性乙型肝炎患者中HBeAg阴性与阳性临床特点比较分析

A comparison of clinical characteristics of 273 cases of HBeAg-negative and HBeAg-positive chronic hepatitis B

目的通过大样本横断面回顾性调查,了解HBeAg阴性和HBeAg阳性两类慢性乙型肝炎患者临床相关因素的异同。方法对237例HBeAg阴性与HBeAg阳性的慢性乙型肝炎患者住院病历进行回顾性调查,分析这两组患者肝功能、诊断构成、HBV DNA定量以及免疫学检查等指标的差异。结果HBeAg阴性组年龄较大,HBV DNA含量较低,慢性重症肝炎、肝硬化和肝癌构成比高。结论HBeAg阴性慢性肝炎近年来患病率增高,患者年龄大,预后差,是今后防治的重点。

Objective To investigate the clinical characteristics of HBeAg-negative and HBeAg-positive chronic hepatitis B （CHB）. Methods A total of 273 hospitalized CHB cases were analyzed retrospectively. The serum ALT values, HBV DNA levels and hepatic inflammation and fibrosis were analyzed by their serum HBeAg status. Results Compared with the HBeA＇g positive group, the HBeAg negative group were older and had lower HBV DNA levels, but the constituent ratios of chronic serious hepatitis, hepatic cirrhosis and hepatoma were higher. Conclusion The HBeAg-negative case ratio increased in recent years, and patients are aged and have bad prognosis, more emphasis should be put on HBeAg-negative case.