犬类MHC复合体Ⅱ类基因研究进展

Progress in Research of Canine Major Histocompatibility Complex Class Ⅱ Genes

概述了犬类MHCⅡ类基因的物理结构图谱,对基因的结构、功能及表达、基因分型方法、基因多态性、基因与疾病的关联研究等作了详细的综述,指明了对犬类MHCⅡ类基因的研究利于其抗病育种,对人类自身免疫性疾病和器官移植等方面具有重要现实意义。

The canine major histocompatibility complex（MHC） class Ⅱ genes are introduced briefly in this article.The physical map,gene structure,gene function and expression,genotyping methods,polymorphism and the association with diseases of canine MHC class Ⅱ region genes are reviewed in details.It is pointed out that the investigation of MHC class Ⅱ genes in dogs would make a large contribution to the research on disease resistance breeding,the human autoimmune diseases and organ transplantation.