玻璃体腔注射气体联合Avastin治疗年龄相关性黄斑变性所致黄斑区网膜下新鲜出血

Intravitreal Injection of Avastin and Gas for Subfoveal Hemorrhage in Age-related Macular Degeneration

目的观察玻璃体腔注射气体联合Avastin治疗年龄相关性黄斑变性所致黄斑区网膜下新鲜出血的临床效果。方法 3例3眼,年龄48～72岁,男1例,女2例。出血时间3～14d,视力HM～FC。经眼底检查、FFA、ICGA、OCT证实为年龄相关性黄斑变性。术前抗生素眼水点眼,手术室无茵条件下于角膜缘后4mm注入C_3F_8 0.3～0.6ml,Avastin 1.25mg/0.05 ml。术后坐位且平视,术后1d、3d、1周、1个月复查眼底,观察出血吸收情况。术后1个月行眼底检查、FFA、ICGA、OCT检查。结果术后3眼视力均有不同程度提高,最好视力提高至0.4,出血部分吸收或被推移离开黄斑部。术后1眼出现高眼压,应用局部药物后控制到正常范围。结论玻璃体腔注射气体联合Avastin治疗年龄相关性黄斑变性所致黄斑部网膜下新鲜出血取得较好临床效果。

Objective To observe the effect of intravitreal injection of Avastin and air on subfoveal hemorrhage in age-related macular degeneration. Methods Three patients with subfoveal hemorrhage for 3 -14 days（48 -72 years old） were chosen, a man and two women. The age-related macular degeneration was diagnosed by the examinations of ocular fundus with direct or indirect ophthalmoscope,FFA, ICGA and OCT. The patients got antibiotic eyedrops preoperation, 1.25mg Avastin and 0.3 -0.6ml C3F8 were gived by intravitreal injection. The head was kept high and the eye orthophoria after operation. The absorbtion of subfoveal hemorrhage was osbserved. Results All patients got a better acuity vision, the hemorrhage were partly absorbed or removed from the macula. Intraocular hypertension occurred in one eye,which was kept normal by topical remedy. Conclusion Intravitreal injection of Avastin and gas has better clinical effect on subfoveal hemorrhage in age-related macular degeneration, but it needs long-term and large sample clinical observation.