β_2 B-MG与mALB联合检测对系统性红斑狼疮、糖尿病、高血压患者早期肾功能损害诊断价值的探讨

The Clinical Significance of β_2 B-MG and mAlb on Early Renal Dysfunction in patients with Systemic Lupus Erythematosus,Diabetes,Hypertension

目的探讨血、尿β_2B-MG、尿微量白蛋白(mALB)对系统性红斑狼疮(SLE)、糖尿病、高血压病患者早期肾脏损害的临床意义。方法采用放射免疫法测定血、尿β_2B-MG、mALB,并进行对照分析。结果与对照组相比,SLE、糖尿病、高血压病患者血、尿β_2B-MG、尿mALB均明显增加,差异具有统计学意义(P<0.05),三者联合检测阳性率高于单一检测。结论血、尿β_2B-MG,尿mALB联合检测能对早期肾小球滤过功能和肾小管重吸收功能进行评价,是发现SLE、糖尿病、高血压病早期肾脏损害的敏感指标。

Objective To explore the clinical significance of blood and urine β2 B-MG and Microalbumin （mALB） on early diagnosis of kidney damage in patients with systemic lupus erythematosus （SLE） , diabetes, hypertension. Methods The urine and blood β2 B-MG and mALB were detected by radioimmunoassay（ RIA）. The contrast analysis was taken among each other. Results Compared with the control group,the level of blood and urine β2 B-MG,urine mALB in patients with SLE, diabetes, hypertension increased significantly（ P 〈 0.05 ）. The positive rate for detecting the above three parameters together were higher than that of the single one. Conclusions Combined detection of blood and urineβ2 B-MG, urine mALB is reliable to evaluate the early impairment of glomerular filtration rate and tubular reabsorption function. They are sensitive indicators for early kidney damage in patients with SLE, diabetes, hypertension.