胃镜下硬化剂注射联合药物治疗食管静脉曲张出血

Combination Therapy in Bleeding Esophageal Varices with Under Gastroscope Injection of Sclerosing Agent and Drug Treatment

目的:观察比较胃镜下硬化剂注射联合药物治疗和单纯硬化剂注射治疗、药物治疗食管静脉曲张出血的疗效。方法:95例肝硬化并食管静脉曲张出血患者,分成三组。32例患者给予硬化剂注射联合药物治疗,31例患者给予硬化剂治疗,32例患者给予药物治疗。观察三组患者急诊止血率,近期出血率、远期再出血率、曲张静脉消失率、曲张静脉复发率。结果:联合组、硬化剂组、药物组急诊止血率分别为93.8%、90.3%、68.8%;联合组、硬化剂组、药物组近期出血率分别为6.3%、9.7%、46.9%;联合组、硬化剂组、药物组曲张静脉消失率分别为90.6%、83.9%、1.9%;联合组、硬化组与药物组急诊止血率、近期出血率、曲张静脉消失率有显著差异。联合组、硬化剂组、药物组远期出血率分别为9.4%、59.4%、31.3%;联合组、硬化剂组、药物组曲张静脉复发率分别为18.8%、45.2%、87.5%;联合组与硬化组、药物组远期出血率、曲张静脉复发率有显著差异。结论:胃镜下硬化剂注射联合药物治疗食管静脉曲张出血可显著提高疗效。

Objective：To observe and compare the treatment effect of combination therapy with injection of sclerosing agent and drug treatment;simple injection of sclerosing agent;and drug treatment in the bleeding esophageal varices.Methods：Ninety-five cases of hepatic cirrhosis and bleeding esophageal varices.Patients were divided into three groups：32 patients were given the combination therapy with injection of sclerosing agent and drug treatment（union group）.31 examples patients were given the injection of sclerosing agent（hardening agent group）.32 examples patients were given the drug treatment（drug group）.In the course of treatment we observed patient emergency hemostasis rate;recent hemorrhage rate;long-term recurring hemorrhage rate,varicose vein disappearance rate,varicose vein relapse rate.Results：The emergency hemostasis rate of Union group、hardening agent group、drug group is respectively 93.8%,90.3%,68.8%;the recent hemorrhage rate of union group,the hardening agent group,and the drug group is respectively 6.3%,9.7%,46.9%;The union group,the hardening agent group,the drug group varicose vein disappearance rate respectively is 90.6%,83.9%,1.9%.The emergency hemostasis rate;recent hemorrhage rate;varicose vein disappearance rate among three groups have the significant difference.The union group,the hardening agent group,the drug group long-term recurring hemorrhage rate,respectively is 9.4%、59.4%、31.3%;The union group,the hardening agent group,the drug group varicose vein relapse rate respectively is 18.8%,45.2%,87.5%.The union group compares with the hardening agent group,the drug group to have the remarkable difference in long-term recurring hemorrhage rate,varicose vein relapse rate.Conclusion：Combination therapy in bleeding esophageal varices with under gastroscope injection of sclerosing agent and drug treatment may remarkably enhance the curative effect.