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白藜芦醇对人脑胶质瘤U251细胞中凋亡相关因子Caspase-3的表达影响 被引量：1

Effect of Resvratrol on the Expression of Caspase-3 in U251 Cell
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摘要 目的:探讨白藜芦醇对人脑胶质瘤U251细胞的凋亡相关因子caspase-3的作用。方法:应用RT-PCR方法和Western-blot分别检测凋亡因子caspase-3的RNA和蛋白水平的表达。结果:白藜芦醇能明显促进U251细胞的凋亡相关因子caspase-3的表达,存在剂量依赖与时间依赖性。结论:白藜芦醇能通过caspase-3途径诱导U251细胞的凋亡。 Objective：To study the effects of Resvratrol on the expression of caspase-3 in U251 Cell.Methods：The mRNA expression of caspase-3 in U251 Cell was detected by RT-PCR,and the protein expression were detected by Western blot.Results：The mRNA and protein expressions of caspase-3 were induced by Resvratrol with a dose and time dependent.Conclusion：Resvratrol can induce U251 cell apoptosis.The effects of Resvratrol on caspase-3 in U251 cell may provide a theoretic basis on future therapy of anti-tumor.
作者 陈忠勇 彭强
机构地区 四川省大邑县人民医院 四川省泸州医学院附属医院
出处 《华西医学》 CAS 2009年第8期2139-2141,共3页 West China Medical Journal
关键词 白藜芦醇 脑胶质瘤 U251细胞 细胞凋亡 CASPASE-3 resvratrol brain glioma U251 Cell apoptosis caspase-3
分类号 R739.4 [医药卫生—肿瘤] R285 [医药卫生—中药学]
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参考文献9

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共引文献44

同被引文献11

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二级引证文献1

华西医学
2009年 第8期

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