摘要
PD-1（programmed cell death 1）是近年新发现的一个负性共刺激信号分子，其配体为PD-LI和PD—12，同属于CD28／B7家族。PD-1／PD-L通路能削弱、限制和／或终止T细胞和APC等细胞的活化及效应功能，在慢性HBV感染的发病机制中发挥了重要作用。
Programmed cell death-l（PD-1） is one of the negative co-stimulate molecules found recently, and its ligands（PD-L1 and PD-L2） belong to CD28/B7 family. This pathway can provide inhibitory signals that can regulate the fine-tuning,inhibition and activation of T-cell and APC responses. It plays an important role in the chronic hepatitis B pathogenesis.
出处
《国际流行病学传染病学杂志》
CAS
2009年第5期343-346,共4页
International Journal of Epidemiology and Infectious Disease
基金
国家自然科学基金（30700698）
