麦氏酸缩取代-4-甲酰基吡唑衍生物的合成及结构性质

Synthesis and Structure Character of the Condensation Products of Meldrum's Acid and Substituted-4-formylpyrazole Derivatives

无水乙醇作溶剂,采取油浴加热和微波辐射加热2种方法,取代-4-甲酰基吡唑和麦氏酸通过Knoevenagel缩合反应合成了5种新型的吡唑环类化合物,以化合物2a为例进行了晶体结构的表征。

Five pyrazole derivatives were synthesized by the Knoevenagel condensation reaction of Meldrum＇s acid with substituted-4-formylpyrazole with absolute ethanol as solvent under heating in oil-bath or microwave irradiation. The crystal structure of compound 2a was characterized.