头孢哌酮/舒巴坦对非发酵革兰阴性杆菌的抗菌活性

Antimicrobial Activity of Cefoperazine/sulbactam for Non-fermentative Gram-negative Bacilli

目的调查头孢哌酮/舒巴坦对医院非发酵革兰阴性杆菌的体外抗菌活性情况,了解头孢哌酮/舒巴坦的体外抗菌作用。方法收集医院2008年6月1日-2009年6月1日临床标本中分离到非发酵菌362株,并检测其对9种抗菌药物的耐药性。结果医院非发酵菌感染以铜绿假单胞菌、鲍氏不动杆菌、嗜麦芽寡养单胞菌、洋葱伯克霍尔德菌为主;其对头孢哌酮/舒巴坦的耐药率分别为29.2%、20.8%、25.0%、27.3%,其抗菌活性优于亚胺培南和美罗培南,更强于哌拉西林/他唑巴坦。结论医院非发酵菌感染耐药率高,且多药耐药严重,头孢哌酮/舒巴坦对治疗多药耐药非发酵菌感染具有广阔的临床应用前景。

OBJECTIVE To investigate the antimicrobial activity in vitro of cefoperazine/sulbactam for non- fermentative Gram-negative bacilli and analyze its antimicrobial capacity in vitro in comparison with imipenem and other antimicrobial drugs. METHODS The 362 clinical strair/s of non-fermentative Gram-negative bacilli were cellected from Jun 1.2008 to Jun 1 ,2009 .The drug resistance of the strains to 9 antibiotics was decetected.REULTS The primary non-fermentative Gram-negative bacilli were Pseudomonas aeruginosa ; Acinetobaeter baumannii, Stenotrophomonas maltophilia and Burkholderia cepacia in our hosipal. The resistant rates to cefoperazine/sulbactam were 29. 2%, 20. 8%, 25. 0% and 27. 3%, respectively. Cefoperazine/sulbactam was better than irnipenem and meropenem and far better than piperacillin/tazobaetam. CONCLUSIONS The resistant rate of non-fermentative Gram-negative bacilli is very high, and it shows multi-drug resistance. The results show cefoperazine/sulbaetams is useful for non-fermentative Gram-negative bacilli infection with multi-drug resistance.