纳洛酮治疗新生儿缺氧缺血性脑病的血清NSE动态变化与意义被引量：1

Dynamic changes of plasma neuron-specific enolase level in neonates with hypoxic-ischemic encephalopathy treated by Naloxone

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摘要目的研究纳洛酮治疗新生儿缺氧缺血性脑病患儿血清神经元特异性烯醇酶(NSE)的动态变化及其临床意义。方法将新生儿科住院的80例中重度新生儿缺氧缺血性脑病患儿随机分为常规治疗组和纳洛酮治疗组。纳洛酮治疗组在常规治疗基础上加用纳洛酮治疗,0.05～0.10mg/(kg·d),加入10%葡萄糖液30mL静滴,维持4～6h,疗程5～7d。治疗前后分别检测血清NSE,同时以30例正常新生儿组作对照。治疗前、治疗1个疗程后和生后28d各进行NBNA测定1次。结果纳洛酮治疗组和常规治疗组治疗后血清NSE有显著下降,纳洛酮治疗组比常规治疗组下降更显著(P<0.05)。纳洛酮治疗组NBNA评分明显好于常规治疗组(P<0.05)。结论纳洛酮治疗新生儿缺氧缺血性脑病具有十分重要价值,血清NSE是动态观察HIE治疗效果的一个指标。 [ Objective ] To study the dynamic changes and clinical significance of plasma neuron-specific enolase level in neonates with hypoxic-ischemie encephalopathy treated by Naloxone. [Methods ] 80 cases of HIE were randomly divided into routine treatment group and Naloxone treatment group, 30 cases of healthy neonates as control group. Injection of Naloxone was added in the Naloxone ＂treatment group 0.05-0.10 mg/（kg ·d）, 5-7 days as a course of treatment. NSE and NBNA marks were indexed for evaluation. [ Results ] The serum NSE level of routine treatment group and Naloxone treatment group were significantly decreased, and Naloxone treatment group was significantly lower than that of routine treatment group （P 〈0.05）. The NBNA of Naloxone group was significantly higher than that of routine treatment group （P 〈0.05）. [ Conclusion ] The treatment of Naloxone has a more important value in HIE, and NSE was a valuable indexes.

作者卓培培

机构地区广西省钦州市妇幼保健院儿科

出处《中国现代医学杂志》 CAS CSCD 北大核心 2009年第19期2962-2964,共3页 China Journal of Modern Medicine

关键词脑缺氧脑缺血新生儿纳洛酮神经元特异性烯醇酶 cerebral anoxia cerebral ischemic neonates naloxone neuron-specific enolase （NSE）

分类号 R722.12 [医药卫生—儿科]

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