阿卡波糖对缺血性心脏病伴糖耐量异常患者的干预作用研究

Effect of acarbose on coronary atherosclerotic heart disease complicating impaired glucose tolerance

目的探讨阿卡波糖对缺血性心脏病伴糖耐量异常患者的干预作用。方法收集缺血性心脏病伴糖耐量异常患者共187例,分为试验组(阿卡波糖干预组)97例;对照组90例,平均随访3.5年。观察其血糖及心血管事件的发生情况。结果187例患者,死亡6例,两组BMI、TG较治疗前均显著下降(P<0.05),试验组OGTT2h、HbA1c较治疗前均显著下降(P<0.05);急性心肌梗死发生率、新发生的心绞痛发生率及总的心血管事件发生率显著降低(P<0.05);试验组发展为DM数较对照组显著降低(P<0.05)。结论阿卡波糖对缺血性心脏病伴糖耐量异常患者进行干预,能有效降低心血管事件的发生及减少DM的发生率。

[ Objective ] To explore the effect of acarbose on coronary atherosclerotie heart disease complicating impaired glucose tolerance. [Methods ] 187 case patients with coronary atherosclerotie heart disease complicating impaired glucose tolerance were divided into two groups, test group 97 case was treated with acarbose, and other treatments were as same as the control group, to survey the BG levels in blood and new occurred cardiovascular event. [ Results ] Of 187 cases, 6 patients were dead, after treatment, the levels of BMI and TG of two groups were significantly lower than pretherapy. In test group, levels of OGTI＂ 2h, HbAle were significantly lower than pretherapy, incidence of acute myocardial infarction, angina pectoris, total cardiovascular event and diabetes were significantly lower than the control group＇s. [ Conclusions] Acarbose can reduce cardiovascular event and diabetes in patients with coronary atherosclerotic heart disease complicating impaired glucose tolerance.