牛心朴子生物碱对小鼠细胞免疫功能的影响

Effects of Cynanchum komanovii alkaloid on Cellular Immune Function of Mice

[目的]研究牛心朴子生物碱对小鼠细胞免疫功能的影响。[方法]取32只小鼠,按灌药剂量分为12、24、48mg/kg.bw3个试验组和1个蒸馏水对照组(0.5ml/d),连续给药30d,分别观察牛心朴子生物碱对小鼠体重、脏器指数、腹腔巨噬细胞吞噬作用及外周血T淋巴细胞数量的影响。[结果]与对照组相比,饲喂3个浓度牛心朴子生物碱后小鼠体重及脏器指数、腹腔巨噬细胞的吞噬机能及外周血液中T淋巴细胞数量均有所降低。[结论]在该试验条件下,一定浓度的牛心朴子生物碱对小鼠的免疫功能有抑制作用。

[ Objective] The research aimed to study the effect of Cynanchum komanovii alkaloid on cellular immune function of mice[ Method] 32 mice were divided into three experimental groups given medicament with daily dose of 12, 24, 48 mg/kg, bw and a control group infused with 0.5 ml/d distilled water in 30 days. Effects of C. komanovii alkaloid on mice body weight and viscera index, the phagoeytosis of peritoneal maerophage, the T lymphocyte count of peripheral blood were observed. [ Result] Compared with control group, those items of the medicated groups decreased. [ Conclusion] Under the above conditions, a certain concentration C. komanovii alkaloid has inhibitory effect on the immune function of mice.