血清CRP值对川崎病早期诊断和预后判断的意义

The Significance of Serum CRP to Early Diagnosis of Kawasaki Disease and Prognosis Judgment

目的:观察川崎病(KD)患儿血清CRP值变化并分析其对KD的早期诊断和判断预后的意义。方法:对诊断KD的24例患儿分别测定其急性期入院时及正规抗感染治疗3天后的血清CRP值。同时测定24例同期年龄相仿发热患儿(非KD及血液系统疾病)血清CRP值作为对照。KD患儿均行心脏彩色多普勒超声检查。对有和无冠状动脉异常患儿血清CRP值分别进行比较。结果:KD患儿CRP值在抗感染治疗后较急性期升高显著(P<0.01)。冠状动脉异常患儿与无异常患儿比较无显著差异性(P>0.05)。结论:KD患儿早期血清CRP值呈进行性增高,可作为KD早期诊断的重要依据;但是否能以CRP值高低程度来判断预后还有待进一步研究。

Objective：To observe the changes of serum CRP of the children patients who have Kawasaki Discase（KD）,and analyzc the significance of Serum CRP to early diagnosis of Kawasaki Disense and prognosis judgment.Methods：To test the serum CRP of 24 cases which chidren patients have been diagnosed of KD at acute stage hospitalization and at 3 days later after normal anti-infection treatment respectively.At the same time,test the serum CRP of 24 cases which children patients are at similar age who has fever（Not KD or hematological disease）as control study.KD children patients all have their heart Doppler Ultrasound tested.Compare serum CRP between children patients who have coronary artery anomalies and those who do not have coronary artery anomalies.Results：The CRP of children patients who have KD is significantly raised after anti-infection treatment while compared with which at the acute stage （P〈0.01）.There is no significant difference between children patient who have coronary artery anomalies and those who do not have coronary artery anomalies（P〉0.05）.Concluslons：At the early stage,the CRP of children patients who have KD is increased in progressive,it can be an important evidence for early diagnosis of KD.However,whether we can judge the prognosis by CRP still remains further research.