肝素抗凝疗法治疗小儿过敏性紫癜及远期随访

Heparin Anticoagulant Therapy Treats the Young Child Allergic Purpura and the Long-term Follow-up Visit

目的:观察43例过敏性紫癜的住院患儿采用以肝素为主的抗凝疗法治疗的临床效果。方法:治疗组43例采用肝素等抗凝疗法,对照组32例采用其他抗过敏及统一组方的中药方法。结果:皮疹消退情况:治疗组大部分于治疗后1周内消失,对照组则明显延长■<0.05,有显著性差异。随访4年,治疗组复发或反复率明显少于对照组,差异有显著性,P<0.05。治疗组对过敏性紫癜合并肾损害的病例治愈率明显高于对照组,差异有显著性,P<0.05。关节症状消失时间、紫癜停出时间、腹痛缓解时间两组间无统计学差异。结论:抗凝疗法确实可行,副作用少,可减少过敏性紫癜的复发和反复,对肾脏损害有一定的防治作用。

Objective：Observe clinical effects of allergic purpura hospitalized children patients who had received heparin as main medicine anticoagulant therapy.Methods：The treatment group 43 examples used heparin anticoagulant therapies,the control group 32 examples used other anti-allergy and the unification prescribe of Chinese medicine method.Results：The Skin rash of most petients have disappeared within one week in treat group,it shorter than the control group obviously,P〈0.05,they have a significance difference.We have made a follow-up visit for 4 years.the recrudescence or recurrence rate of treatment group obviously fewer than the control group repeatedly, the difference has the significance,P〈0.05.The cure rate of the treatment group is higher than the control group obviously in the allergic purpura merge kidney harm case,the difference has the significance,P〈0.05.The two groups have no statistic differenees in the joint symptom vanishing time,the purpura stop time and the abdominal pain alleviation time.Conclusions：The Heparin anticoagulant therapy is truly feasible,the side effects are few.It may reduce the rate of the recrudescence and the relapse of the allergic purpura.It also can prevent and treat the kidney damage of child allergic purpura.