摘要
目的:探讨全身麻醉诱导期间通过依次静注丙泊酚-K哒唑仑-芬太尼抑制芬太尼诱发咳嗽反射(fentanyl-cough-reflex,FCR)发生的有效性。方法:60例择期行全身麻醉的手术患者,ASAⅠ或Ⅱ级,随机均分为丙泊酚-咪哒唑仑-芬太尼顺序诱导组(S组,实验组,n=30)、和芬太尼-丙泊酚-咪哒唑仑顺序诱导组(D组,对照组,n=30)。比较麻醉诱导期间两组患者FCR发生的时间、发生率和程度。结果:丙泊酚-咪哒唑仑-芬太尼顺序诱导组(S组)较芬太尼-丙泊酚-咪哒唑仑顺序诱导组(D组)FCR的发生率和程度显著降低(P<0.01)。结论:丙泊酚-K哒唑仑-芬太尼顺序诱导组能有效抑制芬太尼全麻诱导期间FCR的发生率和程度。
Objective：To evaluate the effectiveness of propofol combined with midazolun on fentanyl-induced coughing response. Methods：Sixty adult patients undergoing general anaeshesia were randomly allocated into two groups with 30 cases each,The patients in group S were given propofol-midazolun-fentanyl in turn and those in group Dwere given fentanyl-midazolan-propofol in turn and injected within 30s.The coughing events were recorded within two minutes after fentanyl injection.Results：The morbidity of coughing response was 42.5% in groupD,which was significantly higher than 6.7% in group S（P〈0.01）.Conclusions：The patients were given propofol- midazolun-fentanyt in turn is effective in preventing fentanyl-indueed coughing response.
出处
《中国医药导刊》
2009年第11期1887-1888,共2页
Chinese Journal of Medicinal Guide
关键词
丙泊酚
咪哒唑仑
芬太尼
FCR
Propofol
Midazoltm
Fentanyl
Coughing response
