438例念珠菌鉴定分离及临床药敏分析

438 Example Rosary Fungus Appraisal Separation and Clinical Medicine Sensitive Analysis

目的:了解本院住院患者念珠菌分离率情况及真菌对常用抗生素的耐药率以指导临床合理治疗选药。方法:使用科玛嘉显色培养基鉴定念珠菌,采用美国临床实验室标准委员会(NCCLS)推荐的肉汤稀释法进行药敏试验。结果:2006年、2007年、2008年从住院患者标本中分离的念珠菌分别占同期总病原体7.67%、12.03%和14.69%。438株念珠菌中,白色念珠菌、热带念珠菌、光滑念珠菌、克柔念珠菌及其它念珠菌分别占55.48%、23.06%、5.75%、2.28%和13.47%。常用抗真菌药物耐药率依次为:特比奈芬48.86%、氟康唑20.32%、伊曲康唑18.95%、咪康唑15.98%、酮康唑16.67%、5-氟胞嘧啶3.19%、两性霉素B2.51%。结论:2006～2008年临床标本中念珠菌分离率逐年显著上升,咪唑类抗真菌药物的耐药率较高。

Objective：understood that this courtyard in hospital patient rosary fungus separative rate situation and the fungus bear the medicine rate to the commonly used antibiotic to instruct the clinical reasonable treatment to choose the medicine.Methods：Use branch Ma fine colored culture medium appraisal rosary fungus,uses the bouillon dilution method which the US Clinical Laboratory scale Committee （NCCLS）recommends to enter takes a walk the sensitive experiment.Results：2006th 2007,in 2008 from are hospitalized the rosary fungus which in the patient specimen separates to occupy same time the total pathogen separately 7.67%,12.03% and 14.69%.In 438 rosary fungi the white rosary fungus,the tropics rosary fungus,the smooth rosary fungus,the gram supple rosary fungus and other rosary fungus account for 55.48% separately,23.06%,5.75%,2.28% and 13.47%.The commonly used anti-fungus medicine bears the medicine rate is in turn compares nai fragrance 48.86%,fluorine Kang zuo 20.32%,Iraq Qu Kang especially zuo 18.95%,onamot Kang zuo 15.98%,alkone Kang zuo 16.67%,5-fluorine cytosine 3.19%,amphoteric mildew elements B2.51%.Conclusions：In 2006-2008 year clinical specimen the rosary fungus separative rate ovbiously rises year by year,the imidazole class anti-fungus medicine bears the medicine rate to be high.