布洛芬混悬液与对乙酰氨基酚混悬滴剂临床退热疗效比较

Antipyretic Effects of Ibuprofen Suspension and Mixed Paracetamol Suspension Drops

目的观察比较布洛芬混悬液与对乙酰氨基酚混悬滴剂的临床退热疗效。方法选择有发热症状的患儿230例随机分成两组,布洛芬组120例,对乙酰氨基酚组110例,布洛芬组口服布洛芬混悬液7 mg/（kg·次）,对乙酰氨基酚组口服对乙酰氨基酚混悬滴剂10～15 mg/（kg·次）,记录用药后1～6 h的体温变化情况,并做统计学处理。结果布洛芬组与对乙酰氨基酚组在用药2 h之内退热效果差异无显著性（P＆gt;0.05）,3 h后布洛芬组退热效果明显优于对乙酰氨基酚组,4 h后对乙酰氨基酚组体温开始回升,退热率达77.5%,而布洛芬组在用药后6h仍有退热作用,6 h退热率达90%,经统计学处理差异有显著性（P〈0.01）。结论与对乙酰氨基酚混悬滴剂比较,布洛芬混悬液退热效果好,维持时间长,不良反应轻微。

Objective To study the antipyretic effects of ibuprofen suspension and mixed paracetamol suspension drops. Methods 230 children with fever symptoms were randomly divided into two groups：ibuprofen group （120 cases） and paracetamol group （110 cases）. Ibuprofen group took ibuprofen suspension 7 mg/kg each time, paracetamol group took mixed paracetamol suspension drops 10 - 15 kg/kg each time. The changes of temperature were recorded after taking drugs 1 - 6 hours. Results The both antipyretic effects in 2 hours had no significant defference（P 〈0.05）. The antipyretic effects of ibuprofen in 3 hours was significantly better than that of paracetamol group. The temperature of paracetamol group went up in 4 hours. The antipyretic rate was 77.5%. The antipyretic effects of ibuprofen was still remained in 6 hours. Its antipyretic rate was 90%. Conclusion Ibuprofen suspension has better antipyretic effects and keep longer time.